How It Compares to Ozempic, Wegovy and Other Weight Loss Medications

South Africans now have a new option for weight management. In 2025, Mounjaro (tirzepatide) was approved by the South African Health Products Regulatory Authority (SAHPRA) and is available through Aspen Pharmacare. Already making waves internationally, Mounjaro is now here, offering a fresh approach for people looking to lose weight effectively.

Administered via a convenient weekly KwikPen injector, Mounjaro works differently from many existing medications, making it an exciting development for the local market.

What Is Mounjaro?

Mounjaro is a dual-action medication that mimics two hormones, GLP-1 and GIP. These hormones help regulate appetite, hunger and blood sugar levels. By targeting both receptors, Mounjaro not only helps people feel fuller for longer but can also improve metabolic control.

Clinical trials have shown impressive results. About 82% of users lost at least 5% of their body weight, 62% lost 10% or more, and 42% lost 15% or more of their starting weight.

By comparison, Ozempic (semaglutide), which targets only GLP-1, showed slightly lower results: 67% of users lost 5% or more, 37% lost 10% or more, and 18% lost 15% or more (LATimes).

How Mounjaro Compares to Wegovy

Wegovy (semaglutide 2.4 mg) is another popular weight loss injection available in South Africa. Like Ozempic, Wegovy targets GLP-1 receptors but does not target GIP. Clinical trials indicate Wegovy users can lose around 15% of their body weight over 68 weeks.

While Mounjaro and Wegovy can achieve similar weight-loss percentages, Mounjaro’s dual-action mechanism may provide additional benefits in blood sugar control, making it particularly appealing for people with type 2 diabetes or metabolic conditions.

Availability and Cost in South Africa

Both Mounjaro and Wegovy are available through prescription. Mounjaro’s weekly KwikPen injector makes it convenient and easy to use at home.

Costs can vary depending on pharmacy and dosage, so it’s important to check availability and pricing locally. Consulting a healthcare professional can also help you determine which medication aligns best with your health goals and budget.

Things to Consider Before Starting

Before starting any weight loss medication, including Mounjaro, Wegovy or Ozempic, keep the following in mind:

• Consult a healthcare professional: Make sure the medication is safe for you based on your medical history and current medications.
• Be aware of side effects: Common side effects include nausea, vomiting and gastrointestinal discomfort.
• Combine with lifestyle changes: These medications are most effective when paired with a balanced diet and regular exercise.

Which Medication Might Be Right for You?

Mounjaro may be ideal for those seeking stronger weight loss and improved blood sugar control. Wegovy is a good option if your primary goal is weight loss, while Ozempic may suit individuals who need moderate weight loss alongside diabetes management.

Individual results vary, so personalized medical advice is essential.

The arrival of Mounjaro in South Africa expands the options for weight management. With its dual-action mechanism and strong clinical results, Mounjaro provides a promising tool alongside Ozempic and Wegovy.

If you’re considering a weight loss injection, make sure to consult a healthcare professional to determine the best option for your unique needs.